Tom Holland Peter Parker / Spider-Man Jake Gyllenhaal Quentin Beck / Mysterio Samuel L. Jackson Nick Fury Marisa Tomei May Parker Jon Favreau Happy Hogan Zendaya MJ Jacob Batalon Ned Leeds Tony Revolori Flash Thompson Angourie Rice Betty Brant Remy Hii Brad Davis Martin Starr Mr. Harrington J.B. Smoove Mr. Dell Jorge Lendeborg Jr. Jason Ionello Cobie Smulders Maria Hill Numan Acar Dimitri Zach Barack Zach Zoha Rahman Zoha Yasmin Mwanza Yasmin Joshua Sinclair-Evans Josh Tyler Luke Cunningham Tyler Sebastián Viveros Sebastian Toni Garrn The Seamstress Peter Billingsley William Ginter Riva Clare Dunne Victoria Nicholas Gleaves Guterman Claire Rushbrook Janice J.K. Simmons J. Jonah Jameson Dawn Michelle King E.D.I.T.H. (voice) Jeroen van Koningsbrugge Dutch Soccer Hooligan Michael de Roos Dutch Soccer Hooligan Jan-Paul Buijs Dutch Soccer Hooligan Sergio Pierattini Venetian Glassblower Anjana Vasan Queens Reporter Brian Law Queens Reporter Evelyn Mok Queens Reporter Giada Benedetti Italian Customs Office Lukáš Bech Helpful Dutch Man Alessandro Giuggioli Italian Street Vendor Pat Kiernan Pat Kiernan Shari Abdul High School Reporter (uncredited) Mari Alexandrova Tourist in Venice (uncredited) Kristen Alminta Police Officer (uncredited) Vincent Angel Midtown High Student (uncredited) Peter Arpesella Airplane Pilot (uncredited) Lasco Atkins Salvation Army guest (uncredited) Sitara Attaie Dutch Lady (uncredited) Peter Bankolé Mob Boss (uncredited) Blair Barnette Queens Reporter (uncredited) Tuwaine Barrett Officer Bristow (extended cut) Anna Benamati Shop Owner in Venice (uncredited) Avondre E.D. Beverley High School Student (uncredited) Bruno Bilotta Mob Boss (uncredited) Sharon Blynn Soren (uncredited) Dante Brattelli High School Student (uncredited) Sokol Cahani Mob Boss (uncredited) Daphne Cheung Passport Clerk (uncredited) Massi Furlan Flight Attendant (uncredited) Joseph Long Mob Boss (uncredited) Ben Mendelsohn Talos (uncredited) Anthony Molinari Mob Guy (uncredited) Hiten Patel British Station Staff (uncredited) Annie Pisapia Traveler (uncredited) Joakim Skarli London Tourist (uncredited) Faith Tarby Perfumed Lady (uncredited) Aristou Meehan Italian Boy (uncredited) Eric Patrick Cameron Midtown High Student (uncredited)