Ryan Reynolds Wade Wilson / Deadpool / Juggernaut (voice) Josh Brolin Cable Morena Baccarin Vanessa Julian Dennison Firefist Zazie Beetz Domino T.J. Miller Weasel Leslie Uggams Blind Al Karan Soni Dopinder Brianna Hildebrand Negasonic Teenage Warhead Jack Kesy Black Tom Eddie Marsan Headmaster Shioli Kutsuna Yukio Stefan Kapicic Colossus (voice) Randal Reeder Buck Nikolai Witschl Head Orderly Frye Thayr Harris Sergei Valishnikov Rob Delaney Peter Lewis Tan Shatterstar Bill Skarsgård Zeitgeist Terry Crews Bedlam Brad Pitt Vanisher Paul Wu Hong Kong Boss Robert Maillet Sluggo Alan Tudyk Luke - Redneck #1 Matt Damon Redneck #2 Michasha Armstrong Swat Captain (School) Joe Doserro Bus Driver Hayley Sales Cable's Wife Islie Hirvonen Cable's Daughter Jagua Arneja Tree Trimmer #1 Gerry South Tree Trimmer #2 Mike Dopud Prison Guard Luke Roessler Cereal Kid Andy Canete Neighbor #1 Tanis Dolman Neighbor #2 Hunter Dillon Branding Boy Sala Baker Older Firefist Sonia Sunger News Reporter (Irene) Paul Wernick News Cameraman Rhett Reese News Helicopter Pilot Abiola Uthman Chinook Pilot Tony Bailey Black Tom Gang Member Alex Kliner Park Bench Couple David Leitch Ground Chuck Mutant Valencia Budijanto Zoo Kid Stefania Indelicato Bystander Paul Lazenby Strip Club Baddie Noah Beggs Strip Club Baddie Andrei Kovski Strip Club Baddie Alicia Morton Vocalist on 'Tomorrow' (voice) Andre Tricoteux On-Set Colossus (uncredited) Lisa Bunting Child Protection Worker (uncredited) Miles Ellis Waving Prisoner (uncredited) Lars Grant Prison Guard 96S (uncredited) Sam Hargrave DMC Guard (uncredited) Nicholas Hoult Beast (uncredited) Simon MacIntyre Business Passerby (uncredited) James McAvoy Charles Xavier (uncredited) Evan Peters Quicksilver (uncredited) Tye Sheridan Cyclops (uncredited) Alexandra Shipp Storm (uncredited) Kodi Smit-McPhee Nightcrawler (uncredited) Scott Vickaryous Thug (uncredited) Dan Zachary Mutant Prisoner (uncredited)