Steve Carell Gru / Chet (voice) Kristen Wiig Lucy Wilde / Blanche (voice) Will Ferrell Maxime Le Mal (voice) Sofía Vergara Valentina (voice) Joey King Poppy Prescott (voice) Stephen Colbert Perry Prescott (voice) Chloe Fineman Patsy Prescott (voice) Miranda Cosgrove Margo / Bree (voice) Dana Gaier Edith / Blair (voice) Madison Polan Agnes / Britney (voice) Pierre Coffin Minions (voice) Steve Coogan Silas Ramsbottom (voice) Chris Renaud Additional Minions (voice) Jason Segel Vector (voice) Benjamin Bratt El Macho (voice) Trey Parker Balthazar Bratt (voice) Sandra Bullock Scarlet Overkill (voice) Jon Hamm Herb Overkill (voice) Taraji P. Henson Belle Bottom (voice) Russell Brand Dr. Nefario