Tom Holland Peter Parker / Spider-Man Zendaya Michelle 'MJ' Jones Benedict Cumberbatch Stephen Strange / Doctor Strange Jacob Batalon Ned Leeds Jon Favreau Harold 'Happy' Hogan Jamie Foxx Max Dillon / Electro Willem Dafoe Norman Osborn / Green Goblin Alfred Molina Dr. Otto Octavius / Doctor Octopus Benedict Wong Wong Tony Revolori Eugene 'Flash' Thompson Marisa Tomei May Parker Andrew Garfield Peter Parker / Spider-Man Tobey Maguire Peter Parker / Spider-Man Angourie Rice Betty Brant Arian Moayed Agent Cleary Paula Newsome MIT Assistant Vice Chancellor Hannibal Buress Coach Wilson Martin Starr Mr. Harrington J.B. Smoove Mr. Dell J.K. Simmons J. Jonah Jameson Rhys Ifans Dr. Curt Connors / The Lizard Charlie Cox Matt Murdock Thomas Haden Church Flint Marko / Sandman Mary Rivera Ned's Lola Rudy Eisenzopf Arena Bystander Kathleen Cardoso Arena Bystander Jonathan Sam Arena Bystander Ben VanderMey Man in Car Zany Dunlap Mom in Car B. Clutch Dunlap Kid in Car Minnah Dunlap Kid in Car Gary Weeks Agent Foster Gregory Konow Donut Shop Boss Carol Anne Dines Donut Shop Waitress Anisa Nyell Johnson School Security Guard Mallory Hoff Reporter Greg Clarkson Reporter Regina Ting Chen Reporter Robert Mitchel Owenby Daily Bugle Lackey Glenn Keogh British Reporter Paris Benjamin British Anchor Taylor St. Clair Protestor Gabriella Cila Crowd Member Darnell Appling Crowd Member Edward Force Donut Shop Patron Cristo Fernández Bartender Tom Hardy Eddie Brock / Venom (uncredited) Jake Gyllenhaal Mysterio / Quentin Beck (archive footage) (uncredited)