Sam Worthington Jake Sully Zoe Saldaña Neytiri Sigourney Weaver Kiri / Dr. Grace Augustine Stephen Lang Colonel Miles Quaritch Kate Winslet Ronal Cliff Curtis Tonowari Joel David Moore Norm Spellman CCH Pounder Mo'at Edie Falco General Frances Ardmore Jemaine Clement Dr. Ian Garvin Giovanni Ribisi Parker Selfridge Britain Dalton Lo'ak Jamie Flatters Neteyam Trinity Bliss Tuktirey "Tuk" Jack Champion Miles 'Spider' Socorro Brendan Cowell Mick Scoresby Bailey Bass Tsireya Filip Geljo Aonung Duane Evans Jr. Rotxo Dileep Rao Dr. Max Patel Matt Gerald Recom Wainfleet Robert Okumu Ta'unui Olecthan Keston John Tarsem Kevin Dorman Recom Mansk Alicia Vela-Bailey Recom Zdinarsik Sean Anthony Moran Recom Fike Andrew Arrabito Recom Prager Johnny Alexander Recom Ja Maria Walker Recom Walker Phil Brown Stringer Jocelyn Christian Bio Lab Tech Joel Tobeck Neuroscientist Phil Peleton Male Med-Tech Jamie Landau Metkayina Warrior Benjamin Hoetjes Mako Sub #1 Gunner Anthony Ahern Mako Sub #2 Gunner Shane Rangi Matador Co-Pilot Tanya Drewery Neurotech #1 Ava Diakhaby Neurotech #2 Chloe Coleman Young Lo'ak CJ Jones Metkayina Interpreter (uncredited) Boris Rehlinger Cpl. Lyle Wainfleet recombiné (V.F.) Alexandre Nguyen Rotxo (V.F.)